Scientist - Upstream Process Development

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Department: Process Development/CMC                                          

Reports to: Group Leader – Upstream Process Development

Direct Reports: N/A                                     


MAIN PURPOSE OF JOB                                                                                                                         

We are seeking an ambitious, highly motivated and experienced Upstream (USP) Scientist to join our team. This is a role where you will be able to apply your experience in a cutting-edge environment working for a growing company in an innovative environment. This is an exciting opportunity for a talented scientist to contribute to the development of novel, state-of-the-art mammalian cell culture upstream processes for exosome-based biotherapeutic products.

We are looking for an individual who is a self-starter, will thrive in a start-up environment, be able to coach and motivate, be able to innovate and relish the sense of accomplishment each day brings in our exciting company.

This position is based at Evox Therapeutics facility at the Oxford Science Park, Oxford, UK and reports to the Group Leader Upstream Process Development.


  • Design and execute experiments to develop and optimise cell culture batch, fed batch and perfusion processes for exosome products.
  • Mammalian cell culture using single use bioreactors such as shake flasks, high throughput systems such as amr15/ambr250 and 2L stirred tank systems and WAVE bioreactors.
  • Apply statistical approaches for process optimisation (DoE, QbD) at small scale (15/250ml ambr high throughput) and translation of small-scale results to process scale-up.
  • Scale up of upstream processes (10-200L) to confirm process performance.
  • Experience of routine analytical techniques such as SDS-PAGE, Western Blotting and biochemical assays is desirable.
  • Support technology transfer activities for commercial manufacturing.
  • Ensure that all experimental and analytical data is documented following data integrity principles.
  • Work collaboratively with Research, Cell Line Development, Downstream Process Development, Research Manufacturing and Quality to develop and establish new techniques and recommend alternative approaches and potential solutions to upstream process development issues.
  • Ensure a healthy and safe working environment and compliance to GMO/ACDP requirements.


Education and Qualifications:

  • PhD or BSc/MSc in Cell Biology, Biochemistry, Biotechnology, Molecular Biology, Biological Sciences, Biochemical Engineering or a related field.

A highly motivated and ambitious scientist with:

  • Ability to work independently.
  • Good conceptual, analytical thinking, problem solving, and organisational skills.
  • Ability to work in a high paced team environment, meet deadlines, and prioritise work from multiple projects.
  • Strong interpersonal and communication skills with demonstrated ability to work within a team environment.
  • Ability to balance multiple priorities and projects at the same time and be able to change priorities as needed by the business.

Experience & knowledge

  • PhD in relevant area with 2+ industrial laboratory experience in biologics and/or cell/viral product process development or BSc/MSc with 5+ years direct industrial laboratory experience as above.
  • Proven industry experience in mammalian suspension cell culture batch and fed-batch process development, optimisation and scale up most probably gained in with protein and/or viral products.
  • Experience of basal medium and feed development, control, and optimisation.
  • Experience in the development of perfusion processes would be advantageous.
  • Experience in adherent cell culture, expansion and scale out would be advantageous but not essential.
  • Understanding and experience of development and establishment of in-process analytical methods as applied to mammalian cell culture processes.



People with PurposeWe are innovative and creative in the way we work and deliver. We treat each other with respect and dignity and work collaboratively to learn from each other’s strengths.

Driven to DeliverWe strive to deliver our objectives, and then look for our next challenge. We recognise our achievements and celebrate our successes.

Agile and AccountableWe respond to challenges impacting our progress and find creative and innovative solutions to overcome obstacles. We are brave and not afraid to change our approach to achieve a positive outcome in optimum time.

Candid and Constructive We communicate with honesty and transparency throughout the team.  We value giving and receiving constructive feedback to each other and our partners.

Or, know someone who would be a perfect fit? Let them know!


Evox Therapeutics
OX4 4HG Oxford Directions +44 (0)1865 819140 View page


  • Private Medical Cover

    Cover offered is for new and pre-existing conditions

  • Life Assurance

    Cover offered is 4 x base salary

  • Holidays

    25 days holiday plus bank holidays

  • Pension

    Employer contribution 5%, employee minimum contribution 5%, however, more than 5% can be contributed if you wish

  • Discretionary Bonus

    Bonus is payable based on a combination of corporate and personal performance

  • Evox Stock Options

    Stock Options are issued once the probationary period is passed

Workplace & Culture

At Evox, values are at the heart of how we operate, how we behave, and how we will drive the growth of our exciting company.

We developed the values internally with all our employees, ones which we could all identify and work with.

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