JOB DESCRIPTION

Section: Translational pharmacology

Reports to: Group leader translational pharmacology

Location: Oxford/London

MAIN PURPOSE OF JOB

As a Preclinical Scientist, you will be a pivotal member of the Research and Translational Medicine team at Evox. You will play a key role in the design, execution and analysis of preclinical studies for the characterisation of Evox’s platforms and therapeutic pipeline.

KEY ACCOUNTABILITIES

• Responsible for hands on delivery of in house studies and support to external studies
• Design and execute in vivo studies and ex-vivo analysis across Evox’s pipeline and platform projects
• Develop and characterise new disease models
• Deliver high quality data to support the progression of new therapeutics through candidate selection and preclinical development

• Responsible for compliance, maintaining rigorous standards and accurate reporting of studies

• Role model the Company values and leadership behaviours as part of a high performing and highly engaged team
• Build strong working relationships with other functions including Research and CMC

PERSON SPECIFICATION

It is expected the candidate will have significant experience in designing and delivering preclinical studies, ideally from an industry setting. The ideal candidate would have experience in metabolic or CNS diseases and biology. Experience of working with newer drug modalities (e.g. mRNA, siRNA or AAV) and drug delivery methods would be highly advantageous. The candidate must have well developed communication skills and the ability to build strong relationships with colleagues and external partners. They should be highly organised, possess good attention to detail and communicate effectively across multi-disciplinary teams. They will be delivery focussed and comfortable working in an agile and team-oriented environment.

Experience & knowledge

• PhD in a relevant subject and post-graduate experience in delivering in vivo data
• Current or recent experience as a PIL holder
• Experience of delivering studies to support drug discovery programmes
• Experience of working with new drug modalities or advanced biological approaches particularly experience working with RNA or AAV genetic therapies is preferred
• Demonstrated ability to apply 3Rs principles in designing studies
• Significant experience in ex-vivo techniques such as Q-PCR, western blotting, microscopy, flow cytometry etc
• Advanced communication skills and track record of progressing projects
• Experience of compiling data, writing reports and providing recommendations based on the data generated
• An entrepreneurial attitude and able to work in a fast-paced and agile environment; self-motivated with a high level of attention to detail whilst keeping objectives in sight
• Excellent communication & interpersonal skills with experience analysing, interpreting, and presenting complex scientific data, whilst appropriately targeting audiences

KEY BEHAVIOURAL ATTRIBUTES – ALL STAFF

People with Purpose – We are innovative and creative in the way we work and deliver. We treat each other with respect and dignity and work collaboratively to learn from each other’s strengths.

Driven to Deliver – We strive to deliver our objectives, and then look for our next challenge. We recognise our achievements and celebrate our successes.

Agile and Accountable – We respond to challenges impacting our progress and find creative and innovative solutions to overcome obstacles. We are brave and not afraid to change our approach to achieve a positive outcome in optimum time.

Candid and Constructive – We communicate with honesty and transparency throughout the team. We value giving and receiving constructive feedback to each other and our partners.