Senior Scientist - Downstream Process Development

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Evox Therapeutics is a privately held, Oxford-based biotechnology company focused on harnessing and engineering the natural delivery capabilities of extracellular vesicles, known as exosomes, to develop an entirely new class of therapeutics. Backed by leading life sciences venture capital groups and supported by a comprehensive intellectual property portfolio, Evox’s mission is to positively impact human health by creating novel exosome-based therapeutics for the treatment of various severe diseases with limited options for patients and their families. Evox has created substantial proprietary technology to modify exosomes using various molecular engineering, drug loading, and targeting strategies to facilitate targeted drug delivery to organs of interest, including the brain and the central nervous system. Exosome-based drugs have the potential to address some of the limitations of protein, antibody and nucleic acid-based therapies by enabling delivery to cells and tissues that are currently out of reach using other drug delivery technologies, and Evox is leading the development within this emerging therapeutic space.


Department: Product Development and Supply/CMC                                  

Reports to: Group Leader - DSP

Direct Reports: N/A 


MAIN PURPOSE OF JOB                                                                                                                         

We are seeking an ambitious, highly motivated and experienced downstream process development (DSP) Senior Scientist to be involved in all aspects of DSP process development. This is an exciting opportunity for a talented scientist to take a leading role in the development of de novo processes for a new class of biotherapeutic products. The CMC DSP team also transfers and supports, as required, developed processes internally to Research Manufacturing and externally to cGMP contract manufacturing organisations.

We are looking for an individual who will thrive in a start-up environment, be able to coach and motivate, be able to innovate and relish the sense of accomplishment each day brings in our exciting company.

This position is based at Evox Therapeutics facility at the Oxford Science Park, Oxford, UK and reports to the Principal Scientist, Downstream Process Development.


  • Develop, optimise and establish robust, scalable and industry leading DSP processes to produce high quality cell engineered exosome products, meeting the requirements for quality and titre.
  • Provide scientific and technical leadership, in downstream process development and transfer into Research manufacturing or cGMP - for example process risk assessments, technology transfer and scale-up.
  • Lead resolution of technical and scientific issues that affect, or have the potential to affect, the development and execution of downstream processes for the manufacture of biologics.
  • Deliver product specific and platform DSP documentation, process flow diagrams and reports ensuring appropriate quality of documentation to support inclusion of data and information in regulatory filings.
  • Work collaboratively with Research, Cell Line Development, Upstream Process Development, Analytical Development, Research Manufacturing and Quality to develop and establish new techniques and recommend alternative approaches and potential solutions to downstream processing issues.
  • Ensure a healthy and safe working environment and compliance to GMO/ACDP requirements.


Education and Qualifications:

  • PhD or BSc/MSc in Cell Biology, Biochemistry, Biotechnology, Food Science, Biological Sciences, Biochemical Engineering or a related field.

A highly motivated ambitious scientist with:

  • Ability to work independently.
  • Good conceptual, analytical thinking, problem solving, and organisational skills.
  • Ability to work in a high paced team environment, meet deadlines, and prioritise work from multiple projects.
  • Strong interpersonal and communication skills with demonstrated ability to work within a team environment.
  • Ability to balance multiple priorities and projects at the same time and be able to change priorities as needed by the business.

Experience & knowledge

  • PhD and 3+ years relevant industrial laboratory experience in biologics and/or cell/viral product downstream process development or BSc/MSc with 6+ years relevant industrial laboratory experience as above.
  • Experience in downstream process development or protein purification, from cell culture harvesting through to drug substance/purified product. This would preferably have been gained working with protein biologics and/or viral vectors; ideally exploiting PAT tools and applying QbD principles. Experience or understanding of mammalian cell culture would be a bonus
  • Experience with chromatography systems such as Akta Purifier/Pure/Avant and a good understanding of chromatography techniques e.g. IEX/SEC/HIC/Affinity. Experience and understanding of tangential flow filtration are also desirable. Experience of scale-up of downstream processes to pilot scale would be a bonus.
  • Experience of routine analytical techniques such as SDS-PAGE, Western Blotting and biochemical assays is desirable. Experience of ELISA, cell based assays, HPLC, NTA and flow cytometry would be a bonus
  • Experience in the application DoE. Experience using JMP would be a bonus.
  • Knowledge of regulatory requirements for the development and manufacture of biologics using from mammalian cell culture is desirable.


People with PurposeWe are innovative and creative in the way we work and deliver. We treat each other with respect and dignity and work collaboratively to learn from each other’s strengths.

Driven to DeliverWe strive to deliver our objectives, and then look for our next challenge. We recognise our achievements and celebrate our successes.

Agile and AccountableWe respond to challenges impacting our progress and find creative and innovative solutions to overcome obstacles. We are brave and not afraid to change our approach to achieve a positive outcome in optimum time.

Candid and Constructive We communicate with honesty and transparency throughout the team.  We value giving and receiving constructive feedback to each other and our partners.

Or, know someone who would be a perfect fit? Let them know!


Evox Therapeutics
OX4 4HG Oxford Directions +44 (0)1865 819140 View page


  • Private Medical Cover

    Cover offered is for new and pre-existing conditions

  • Life Assurance

    Cover offered is 4 x base salary

  • Holidays

    25 days holiday plus bank holidays

  • Pension

    Employer contribution 5%, employee minimum contribution 5%, however, more than 5% can be contributed if you wish

  • Discretionary Bonus

    Bonus is payable based on a combination of corporate and personal performance

  • Evox Stock Options

    Stock Options are issued once the probationary period is passed

Workplace & Culture

At Evox, values are at the heart of how we operate, how we behave, and how we will drive the growth of our exciting company.

We developed the values internally with all our employees, ones which we could all identify and work with.

Already working at Evox Therapeutics?

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