Molecular Pathology Scientist - Translational Pharmacology

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EVOX THERAPEUTICS - BACKGROUND

Evox Therapeutics is a growing, privately held Oxford-based biotechnology company focused on harnessing and engineering the natural delivery capabilities of extracellular vesicles, known as exosomes, to develop an entirely new class of therapeutics. Backed by leading life sciences venture capital groups and supported by a comprehensive intellectual property portfolio, Evox’s mission is to positively impact human health by creating novel exosome-based therapeutics for the treatment of severe diseases with limited options for patients and their families. Evox has created substantial proprietary technology to modify exosomes using molecular engineering, drug loading, and targeting strategies to facilitate targeted drug delivery to organs of interest, including the brain and the central nervous system. Exosome-based drugs have the potential to address some of the limitations of protein, antibody and nucleic acid-based therapies by enabling delivery to cells and tissues that are currently out of reach using other drug delivery technologies, and Evox is leading the development within this emerging therapeutic space.

JOB DESCRIPTION

Department: Translational pharmacology

Reports to: Senior director translational pharmacology

Location: Oxford

MAIN PURPOSE OF JOB                                                                                                                         

As a Molecular Pathology Scientist in Translational Pharmacology, you will be a pivotal member of the Research and Translational Medicine team at Evox.  You will be responsible for establishing molecular pathology at Evox and delivering high quality data and interpretation for Evox’s platform technology and therapeutic pipeline in rare diseases.  

KEY ACCOUNTABILITIES

  • Responsible for the design, execution and interpretation of molecular pathology experiments for translation of Evox’s preclinical pipeline
  • Ensure that all tissue collected is adequately preserved and stored and is compliant with ethical and regulatory standards
  • Developing new methods across several platforms (e.g. IHC, ISH, special stains) to support the specific needs of each project
  • Working seamlessly with scientists in Translational Pharmacology and Research to ensure project progression within agreed timelines
  • Liaising with partners and collaborators to share and transfer methods
  • Role model the Company values and leadership behaviours, cultivating high performing and highly engaged teams
  • Build strong working relationships with enabling functions, including Finance and Facilities

PERSON SPECIFICATION

It is expected that the candidate will have significant experience of establishing molecular pathology techniques and delivering data and interpretation to support diagnosis or drug project progression.  They will be experienced across several different experimental techniques with good problem-solving abilities.  The candidate should also be experienced in microscopy and versed in the latest techniques for image analysis from tissue sections.  They must possess good communication skills and the ability to build strong relationships with colleagues and external partners.  They should be highly organised, have good attention to detail and communicate effectively across multi discipline teams.  They will be delivery focussed and comfortable working in an agile and team-oriented environment. 

Experience & knowledge

  • A minimum of a BSc in a relevant subject and at least 5 years' experience leading and delivering molecular pathology studies
  • High level of competence in morphology of a range of tissues across several species
  • Experience of developing new methods and identifying and establishing new technologies for molecular pathology
  • Proficient in automated image analysis, ideally using advanced software packages
  • Confident in working in a collaborative environment across partners and collaborators
  • Experience gained from industry, the NHS or other regulated environment is strongly preferred
  • Experience of working with new drug modalities or advanced biological approaches particularly experience working with RNA or AAV genetic therapies is preferred
  • An entrepreneurial attitude and able to work in a fast-paced and agile environment; self-motivated with a high level of attention to detail whilst keeping objectives in sight
  • Excellent communication & interpersonal skills with experience analysing, interpreting, and presenting complex scientific data, whilst appropriately targeting audiences


KEY BEHAVIOURAL ATTRIBUTES – ALL STAFF

People with PurposeWe are innovative and creative in the way we work and deliver. We treat each other with respect and dignity and work collaboratively to learn from each other’s strengths.

Driven to DeliverWe strive to deliver our objectives, and then look for our next challenge. We recognise our achievements and celebrate our successes.

Agile and AccountableWe respond to challenges impacting our progress and find creative and innovative solutions to overcome obstacles. We are brave and not afraid to change our approach to achieve a positive outcome in optimum time.

Candid and Constructive We communicate with honesty and transparency throughout the team.  We value giving and receiving constructive feedback to each other and our partners.


Or, know someone who would be a perfect fit? Let them know!

Oxford

Evox Therapeutics
OX4 4HG Oxford Directions careers@evoxtherapeutics.com +44 (0)1865 819140 View page

Benefits

  • Private Medical Cover

    Cover offered is for new and pre-existing conditions

  • Life Assurance

    Cover offered is 4 x base salary

  • Holidays

    25 days holiday plus bank holidays

  • Pension

    Employer contribution 5%, employee minimum contribution 5%, however, more than 5% can be contributed if you wish

  • Discretionary Bonus

    Bonus is payable based on a combination of corporate and personal performance

  • Evox Stock Options

    Stock Options are issued once the probationary period is passed

Workplace & Culture

At Evox, values are at the heart of how we operate, how we behave, and how we will drive the growth of our exciting company.

We developed the values internally with all our employees, ones which we could all identify and work with.


Already working at Evox Therapeutics?

Let’s recruit together and find your next colleague.

email
@evoxtherapeutics.com
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